DICER cleavage fidelity is governed by 5′-end binding pockets

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Some of the hardest problems of programming arise when we are dealing with several computations occurring in parallel, raising issues of synchronization and communication. In the seventies, the issues occupied some of the best minds in the field, including Dijkstra and Lamport. The challenge was to find, for concurrent programming, mechanisms at the same level of clarity, abstraction, understandability and provability as sequential programming. (Dijkstra, for example, did not enjoy it at all when people remarked in jest that semaphores, his invention for concurrent programming, were at the same low level of abstraction as the object of his contempt in sequential programming, goto instructions.)

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